Current Editors: Keith Wagner and Michael Ryan

Past Editors: Tim Allen, Kristyna Gleghorn, Dung Mac, Alex Acosta, William Tausend, Sheila Jalalat, Rebecca Philips, Chelsea Altinger, Lindsey Hunter, Alison Wiesenthal, Leslie Scroggins, Mara Dacso, Ashley Group, Fadi Constantine, Emily Fridlington, Joslyn Witherspoon, Tasneem Poonawalla.

Monday, December 09, 2013

DIG member attends Innovations in Dermatological Sciences Conference

On November 19, 2013 DIG member, Dung Mac (MS2), attended the Innovations in Dermatological Sciences Conference hosted by Rutgers University in East Brunswick, New Jersey. There were numerous topics for discussion including optical nanoparticles (Dr. Rox Anderson), toxicology of nanoparticle (Dr. Nancy Monteiro-Riviere), the utilization of nanomaterials for the diagnosis and treatment of skin disease (Dr. Adam Friedman), drug delivery with nanospheres (Dr. Bozena Michniak-Kohn), StrataGraft tissue as an alternate to autografting deep partial thickness burns (Dr. Cathy Rasmussen), alopecia areata (Dr. Angela Christiano), treatment of dystrophic epidermolysis bullosa intravenously with recombinant collagen 7 (Dr. Mark de Souza), and soy skin care products (Dr. Miri Seiberg).

Is skin a portal for nanoparticle exposure? How can nanoparticle be used to deliver drugs through the skin? In Dr. Monteiro-Riviere’s talk, it was discovered that the majority of nanoparticles do not penetrate past the epidermis layer. In Dr. Michniak-Kohn’s talk, the development of a novel nanoparticle, Tyrosphere, could be used as a delivery system for lipophilic drugs across the skin. Although currently, tyrosphere particles do not penetrate past the epidermis, it was demonstrated that they continually release drug into deeper layers of the skin (increasing the solubility of candidate drugs by as much as 5000 fold without penetration to the vasculature).

What are the developments in optical nanoparticles? Dr. Anderson discussed how gold-antibody nanoparticles could be used to target CD8 lymphocytes and selectively kill them with a laser pulse.  This provided the potential for novel tumor therapy. Additionally, recent development in tattoo removal uses microencapsulated soluble pigments that could serve as an alternative to tattoo ink. These pigments have the benefit of being readily degraded with a laser without scarring. Dr. Anderson also spoke about the use of silica core coated with gold particles that are used to selectively target sebaceous glands and damage them with laser, hinting at a possible use for acne treatment.